ISSN:
1573-8744
Keywords:
osmotic system
;
zero-order drug delivery
;
controlled release
;
theophylline
;
rectal administration
;
steady-state
;
in vivo/in vitro correlation
;
saliva-plasma ratio
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract In vivoand in vitroperformances of a rectally applied osmotic delivery system containing a water-soluble derivative of theophylline were compared. The system was applied in six healthy volunteers during 72 h, and a comparison was made with two conventional dosage forms, a suppository and a solution administered orally, given once. In vitro,a perfect zero-order release rate with the osmotic system was obtained. In all subjects, application of the osmotic system resulted in a constant steady-state theophylline level just as in a long time zero-order i.v. infusion, which strongly suggests that the release rate in vivois zero-order too. The release rate was not influenced by renewing the dosage form after 36 hr or by defecation. The in vivoand in vitrorelease rates were almost identical and subjectindependent.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01059035
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