Publication Date:
2018-05-17
Description:
Leishmaniasis is a vector-borne protozoan disease; it mainly originates from the bite of sandfly and initiated when parasite is transmitted to human at metacyclic flagellated promastigote form. In the current study, a synthesis of a series of 4-substituted benzophenone ethers 1–20 was carried out in good yields and their in vitro antileishmanial activities were also screened. Among synthetic derivatives, 15 compounds 1 , 3 , 5–12 , 15 and 17 – 20 showed antileishmanial activities against promastigotes of Leishmania major with IC 50 values in the range of 1.19–82.30 µg ml –1 , and the values were compared with those of the standard pentamidine (IC 50 = 5.09 ± 0.09 µg ml –1 ). Our study identified a series of new antileishmanial molecules as potential leads. Structures of these synthetic compounds were deduced by different spectroscopic techniques, such as 1 H and 13 C nuclear magnetic resonance, electron impact and high-resolution electron impact mass spectrometry and IR.
Keywords:
organic chemistry, biochemistry, chemical biology
Electronic ISSN:
2054-5703
Topics:
Natural Sciences in General
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