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  • optimal observation times  (1)
  • saliva-serum distribution  (1)
  • 1980-1984  (2)
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  • 1980-1984  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 26 (1984), S. 635-637 
    ISSN: 1432-1041
    Keywords: theophylline ; inhalation ; saliva-serum distribution ; healthy volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Six healthy volunteers received an iv infusion of 317 mg lysine theophylline (equivalent to 197 mg anhydrous theophylline) in order to calculate theophylline clearance by standard methods. They subsequently received a 20 minute inhalation of nebulised lysine theophylline. Serum and salivary theophylline concentrations were measured and all saliva was collected for the first hour. From these concentrations estimates were made of the distribution of theophylline into the blood and saliva with 40% to 94% identified in the blood. Very high salivary concentrations were reached during the inhalation phase with saliva: serum concentration ratios of between 60 and 1600.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of optimization theory and applications 39 (1983), S. 47-58 
    ISSN: 1573-2878
    Keywords: Observation cost ; quadratic cost ; LQG problems ; optimal observation times
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract Feedback control is sometimes applied to a dynamic system operating in a stochastic environment under circumstances where only a limited number of observations can be made. The optimal positioning of ana priori fixed number of observations is considered. A direct approach to this problem yields a dynamic programming functional equation, while a second approach involving an ancillary observation cost leads to a rapid and practical numerical solution.
    Type of Medium: Electronic Resource
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