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  • 1
    Electronic Resource
    Electronic Resource
    Molecular structure of a naturally occurring alcohol dehydrogenase null activity allele inDrosophila melanogaster (1989)
    Springer
    Biochemical genetics 27 (1989), S. 679-688 
    Details
    ISSN: 1573-4927
    Keywords: alcohol dehydrogenase ; null allele ; DNA rearrangement ; Drosophila melanogaster
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract An alcohol dehydrogenase null activity allele,Adh nAH52 , extracted from a natural population ofDrosophila melanogaster has been cloned and sequenced. Compared with the wild-type consensus sequence, the nucleotide sequence ofAdh nAH52 contains eight extra bases in intron 2, adjacent to the 5' splice site. It seems likely that the extra bases result from two structural changes, with a 10-base pair insertion at the same site as a 2-base pair deletion. The insertion includes an 8-base pair duplication of an adjoining region. This structural change alters transcription to give rise to an mRNA which is longer than normal and at 10% of the wild-type level.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00553989
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  • 2
    Electronic Resource
    Electronic Resource
    Molecular structure of a naturally occurring alcohol dehydrogenase null activity allele inDrosophila melanogaster (1989)
    Springer
    Biochemical genetics 27 (1989), S. 679-688 
    Details
    ISSN: 1573-4927
    Keywords: alcohol dehydrogenase ; null allele ; DNA rearrangement ; Drosophila melanogaster
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract An alcohol dehydrogenase null activity allele,Adh nAH52 , extracted from a natural population ofDrosophila melanogaster has been cloned and sequenced. Compared with the wild-type consensus sequence, the nucleotide sequence ofAdh nAH52 contains eight extra bases in intron 2, adjacent to the 5' splice site. It seems likely that the extra bases result from two structural changes, with a 10-base pair insertion at the same site as a 2-base pair deletion. The insertion includes an 8-base pair duplication of an adjoining region. This structural change alters transcription to give rise to an mRNA which is longer than normal and at 10% of the wild-type level.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02396060
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    A KP Element Inserted Between the Two Promoters of the Alcohol Dehydrogenase Gene of Drosophila melanogaster Differentially Affects Expression in Larvae and Adults (1998)
    Springer
    Biochemical genetics 36 (1998), S. 363-379 
    Details
    ISSN: 1573-4927
    Keywords: DROSOPHILA MELANOGASTER ; KP ELEMENT ; TRANSCRIPTION
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract An allele of the Drosophila melanogaster alcoholdehydrogenase (Adh) gene has a 1.15-kb KP elementinserted, in the same orientation as Adh transcription,five nucleotides upstream of the distal transcription start site. The target site-GTCCAAGT — inAdh between nucleotides –13 and –6 isduplicated at both ends of the insertion. Adult flieswith either one or two copies of the allele have lessthan 12% of the alcohol dehydrogenase (ADH) activity of thecontrols. Activity levels are also reduced in larvae,but by a much smaller amount. Quantitative Northernanalyses showed that the low activity level in adults was caused by reduced transcript levels fromthe distal promoter. 5′ RACE experiments indicatedthat adult transcripts were mostly initiated downstreamof the distal promoter but some skipped the first adult exon. In late third-instar larvae thetranscripts present were from the proximal promoter.After the KP element was deleted by an appropriatebreeding program, the distal transcript increased inadults to the control level, but ADH activityincreased to only 50% of the control. No nucleotidechanges were found in the gene that could explain thisdifference.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018749513875
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