ISSN:
1573-9171
Keywords:
glutamic acid
;
diastereoselectivity
;
nucleophilic substitution
;
rate constant
;
arylamine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Kinetics of nucleophilic substitution of halogen in diastereomeric dimethyl 4-bromo- and 4-iodoglutamates withortho-, meta-, andpara-substituted anilines was studied by HPLC. Thethreo-diastereomers of the halogenated derivatives react 3–5 times faster than theerythro ones. The structure of the transition state is discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00698493
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