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  • 1
    Electronic Resource
    Electronic Resource
    Immunogenetic study on the polymorphism of serum α2-lipoproteins in mink. I. Identification and genetic control of five Lpm allotypes (1976)
    Springer
    Biochemical genetics 14 (1976), S. 327-345 
    Details
    ISSN: 1573-4927
    Keywords: allotypes ; lipoproteins ; mink ; identification ; genetic control
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Five allotypes, Lpm 1, Lpm 2, Lpm 3, Lpm 4, and Lpm 5, were detected by isoimmunization in mink sera. Immunoelectrophoresis, preparative ultracentrifugation, and histochemical tests for lipids and esterase permitted reference of these alloantigenic markers to a very high density α2-lipoprotein. Based on population analysis and breeding tests, five genetic units are postulated: Lpm 1, Lpm4, Lpm3,4, Lpm1,2, and Lpm 2,4,5. These units determine the polymorphism of the Lpm system and behave as Mendelian alleles.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00484772
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  • 2
    Electronic Resource
    Electronic Resource
    Immunogenetic study on the polymorphism of serum α2-lipoproteins in mink. II. Identification of allotypes Lpm-7 and Lpm-8 and genetic control of seven markers of the Lpm system (1978)
    Springer
    Biochemical genetics 16 (1978), S. 399-414 
    Details
    ISSN: 1573-4927
    Keywords: allotypes ; lipoproteins ; mink ; identification ; genetic control
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract By means of alloimmunization of mink, two new antigens, Lpm-7 and Lpm-8, were detected in their sera. Lpm-7 and Lpm-8 allospecificities were referred to a very high density α2-lipoprotein (Lpm) by the following criteria: histochemical tests, immunoelectrophoresis, preparative ultracentrifugation, and coalescence of alloprecipitates with heteroprecipitates in double diffusion tests. Genetic analysis indicated that Lpm-7 and Lpm-8, together with the earlier described Lpm-1, Lpm-2, Lpm-3, Lpm-4, and Lpm-5, share a common immunogenetic system. Polymorphism for the seven markers is conditioned by the genetic units Lpm 8, Lpm 4, Lpm 4, 8, Lpm 4, 7, Lpm 3, 4, 8, Lpm 1, 8, Lpm 1, 2, 7, and Lpm 2, 4, 5, 7, which behave as alleles. Of these units, the latter six are probably haploid sets of closely linked genes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00484207
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  • 3
    Electronic Resource
    Electronic Resource
    Immunogenetic study on the polymorphism of serum α2-lipoprotein in mink. III. Ld1 allotype of low-density lipoprotein (1979)
    Springer
    Biochemical genetics 17 (1979), S. 343-350 
    Details
    ISSN: 1573-4927
    Keywords: allotype ; low-density lipoprotein ; mink
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Mink Ld1 antigen of serum low-density lipoprotein was demonstrated by alloantibodies. No genetic relation was found between Ld1 and the Lpm system of very-high-density lipoprotein. The existence of an autosomal dominant gene, coding for the new alloantigenic marker, is postulated on the basis of mink breeding data.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00498974
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  • 4
    Electronic Resource
    Electronic Resource
    Immunogenetic study on the polymorphism of serum α2-lipoproteins in mink. IV. Diallelism at the Ld locus of low-density lipoprotein (1981)
    Springer
    Biochemical genetics 19 (1981), S. 997-1015 
    Details
    ISSN: 1573-4927
    Keywords: allotype ; gene ; low-density lipoprotein ; mink ; evolution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Antibodies against a new allotype, Ld2, of mink low-density lipoprotein (LDL) were obtained by alloimmunization with a preparation of this lipoprotein. The two known allotypes of LDL, designated Ld1 and Ld2, are coded for by codominant alleles of the autosomal Ld locus. This locus is probably involved in the genetic control of the whole serum pool of LDL molecules. In Ld 1 /Ld 2 heterozygotes, LDL is represented by two homozygous types of molecules, Ld1 and Ld2; it has no hybrid molecules bearing both allotypic specificities together. The results suggest that the Ld locus has, presumably, only two alleles in the mink populations studied. Mink LDL having allotypes Ld1 and Ld2 was found to be homologous to human and pig LDLs. Antigenic specificity of Ld1 allotype was established in the sera of a wide phylogenetic range of mammals and in the human LDL. The parallelism between the phylogenetic antiquity of the Ld 1 gene and its high frequency in mink and other species may be attributed to the selective value of this gene, which has been retained unaltered during macroevolution.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00504263
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