ISSN:
1432-1041
Keywords:
Systolic time intervals
;
propranolol
;
clonidine
;
methyldopa
;
essential hypertension
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary Systolic time intervals, including preejection period (PEP) and left ventricular ejecion time (LVET), were studied in patients with permanent essential hypertension before and after intra-venous administration of propranolol 0.2 mg/kg (11 patients), clonidine 0.002 mg/kg (10 patients) and methyldopa 2 mg/kg (12 patients). With propranolol, diastolic blood pressure was unchanged and the heart rate decreased, whilst PEP and LVET were significantly prolonged (P〈0.001). Clonidine caused a fall in blood pressure (P〈0.001), heart rate was slightly reduced, PEP was prolonged (P〈0.001) and there was a significant decrease in LVET at 5 min. With methyldopa, no significant effect was observed after intravenous injection, but 7 days oral administration produced the identical effect as clonidine. These observations suggest that certain antihypertensive drugs may impair left ventricular performance and depress myocardial contractility.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00562932
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