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Cytosolic calcium, oxygen consumption and the intracellular pH of stimulated neutrophils (1988)

Nasmith, Patricia E. ; Grinstein, Sergio

Springer

Bioscience reports 8 (1988), S. 65-76

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ISSN: 1573-4935

Keywords: amiloride ; Na+/H+ exchange ; antiport ; superoxide ; leukocytes

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Chemistry and Pharmacology

Notes: Abstract The cytoplasmic pH undergoes a biphasic change when neutrophils are activated. The role of Ca2+ in initiating these changes was investigated. No correlation was found between the increased cytosolic [Ca2+] and the stimulation of the Na+/H+ antiport. Similarly, the cytoplasmic acidification elicited by activation in Na+-free media was found to be unrelated to [Ca2+]. Reversal of Na+/H+ exchange was also ruled out as the source of the acidification. Data using a variety of soluble activators indicate that metabolic acid generation is largely responsible for the observed drop in cytoplasmic pH.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01128973

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