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  • 1
    Electronic Resource
    Electronic Resource
    The effect of food on the systemic availability of ketoprofen (1988)
    Springer
    European journal of clinical pharmacology 33 (1988), S. 643-645 
    Details
    ISSN: 1432-1041
    Keywords: ketoprofen ; food ; bioavailability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We have studied the pharmacokinetics of ketoprofen, a non-steroidal anti-inflammatory drug, in 12 patients after a single 100 mg oral dose both in fasting conditions and with a meal. Food significantly affected the peak plasma concentration of ketoprofen and decreased its absorption rate. However, the extent of absorption of ketoprofen, as reflected by the area under the plasma concentration time curve, appeared to be unchanged in the presence of food.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542503
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  • 2
    Electronic Resource
    Electronic Resource
    Diffusion of intramuscular ketoprofen into the cerebrospinal fluid (1985)
    Springer
    European journal of clinical pharmacology 29 (1985), S. 319-321 
    Details
    ISSN: 1432-1041
    Keywords: ketoprofen ; diffusion ; cerebrospinal Fluid ; CSF level ; protein binding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Serum and cerebrospinal fluid (CSF) concentrations of ketoprofen have been measured in 36 patients hospitalised for sciatica. Diagnostic lumbar puncture was done 15 min to 13 h after a single 100 mg intramuscular dose of ketoprofen. Serum and CSF were sampled at the same time. Free serum concentrations were determined by equilibrium dialysis. Total and free concentrations were assayed by a highly sensitive and specific HPLC method. Ketoprofen rapidly crossed the blood-brain barrier and was detected in CSF 15 min after its administration. The rapid diffusion can be explained by the high lipid solubility of the drug. The CSF level was in equilibrium with the free serum concentration from the second to the 13th hours.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00544088
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    Paper (German National Licenses)
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