ISSN:
1573-3904
Keywords:
α-aminoisobutyric acid peptides
;
circular dichroism
;
conformational analysis
;
isovaline peptides
;
C-peptide
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract A series of longer analogues of the C-peptide of RNAse A has been synthesized with the aim of assessing the helix induction potential in water of α-methyl, α-amino acids at the N-terminus of the chain. The circular dichroism data indicate that one isovaline residue is effective in increasing the helix content of the 13-residue peptide by about 7%.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1008873910529
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