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  • Artikel  (2)
  • glucose  (1)
  • isoelectric focusing (IEF)  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Effect of chlorpromazine on blood glucose and plasma insulin in man (1977)
    Springer
    European journal of clinical pharmacology 11 (1977), S. 15-18 
    Details
    ISSN: 1432-1041
    Schlagwort(e): Chlorpromazine ; glucose ; glucose utilization ; hyperglycaemia ; insulin ; insulin secretion ; latent diabetes mellitus
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary In three groups of normal subjects and in one group of patients with latent diabetes mellitus a study has been made of the effects of chlorpromazine (CPZ) on blood glucose and plasma insulin. CPZ 75 mg/day for 7 days did not alter the plasma insulin response after oral glucose; nor did CPZ 50 mg/day for 7 days affect the glucose assimilation rate or insulin response to glucose injection. Infusion of CPZ 50 mg in 60 min slightly increased the basal blood glucose level but had no significant effect on basal plasma insulin. The insulin/glucose ratio after the end of the infusion was significantly higher than during the period of infusion of the drug. In latent diabetic patients CPZ infusion significantly diminished the insulin/glucose ratio during an intravenous glucose tolerance test. These results suggest that, whereas prolonged treatment with low doses of CPZ did not modify glucose tolerance and glucose-stimulated pancreatic response, higher acute doses of the drug may induce hyperglycaemia and can inhibit insulin secretion both in normal man and in patients with latent diabetes mellitus.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00561782
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Pituitary protein lipolytic factor(s): Partial purification by isoelectric focusing (IEF) (1983)
    Springer
    The protein journal 2 (1983), S. 455-468 
    Details
    ISSN: 1573-4943
    Schlagwort(e): lipolytic activity ; isoelectric focusing (IEF) ; glycerol release ; lipolysis ; pituitary lipid-mobilizing peptides ; lipolytic hormones
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract Tests were made on highly purified bovine peptidal pituitary factors for lipolytic activity on rat adipose tissue. The lipolytic protein factor from bovine pituitary glands was isolated and characterized by ethanol precipitation, gel filtration, and isoelectric focusing. The supernatant of the homogenized tissue was precipitated with ethanol, the precipitate was lyophilized and resuspended in HCl 1 mmole/liter, the insoluble was discarded, and the supernatant lyophilized. A solution of the lyophilized fraction was fractionated by gel filtration on Sephadex G-75. The bands with lipolytic activity were pooled and lyophilized. Lipolytic activity was determined by incubation of epididimal rat adipose tissue and by successive measurements of free fatty acids and glycerol released in the incubation medium. The gel filtration with the highest lipolytic activity (20.4 µequiv/g per 4 hr and 17.0 µmole/g per 4 hr glycerol) was submitted to isoelectric focusing. The gel filtration still appeared highly heterogeneous, but most of the lipolytic activity was concentrated in the protein band at pH 8.6.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01025419
    Standort Signatur Erwartet Verfügbarkeit
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    Artikel (Nationallizenzen)
    Volltext
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