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  • Electronic structure and strongly correlated systems  (4)
  • intestinal delivery  (2)
  • 1
    Publication Date: 2011-01-11
    Description: Author(s): P. Kusar, T. Mertelj, V. V. Kabanov, J.-H. Chu, I. R. Fisher, H. Berger, L. Forró, and D. Mihailovic The anharmonic response of charge-density wave (CDW) order to strong laser-pulse perturbations in 1 T-TaS_{2} and TbTe_{3} is investigated by means of multiple-pump-pulse time-resolved femtosecond optical spectroscopy. We observe remarkable anharmonic effects hitherto undetected in systems exhibit... [Phys. Rev. B 83, 035104] Published Mon Jan 10, 2011
    Keywords: Electronic structure and strongly correlated systems
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
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  • 2
    Publication Date: 2017-02-04
    Description: Author(s): M. Beck, M. Klammer, I. Rousseau, M. Obergfell, P. Leiderer, M. Helm, V. V. Kabanov, I. Diamant, A. Rabinowicz, Y. Dagan, and J. Demsar In the conventional theory of superconductivity the critical temperature Tc is determined by the electron-phonon coupling constant and the phonon cut-off frequency. The hallmark experiments of McMillan and Rowell demonstrated that bosons (phonons) responsible for pairing can be observed through the frequency dependence of the gap parameter. Determination of the electron-boson coupling strength in high- T c cuprates is, however, not an easy task. One of the promising ways is to measure the energy relaxation rate of photoexcited carriers by using femtosecond real-time techniques. Here, considering the electron relaxation process within the conduction band, it is commonly assumed that the underlying Eliashberg electron-boson coupling function is independent of electron excess energy. Conversely, studies of light-induced suppression of superconductivity in Pr 1 . 85 Ce 0 . 15 CuO 4 reported here imply a strong variation of the electron-boson coupling function on electron energy. Considering the competing scenarios of superconductivity being mediated by either phonons or magnetic excitations, the results suggest that high-energy electrons strongly couple either to phonons or magnetic modes, while the situation is reversed when considering pairing of low-energy electrons. [Phys. Rev. B 95, 085106] Published Fri Feb 03, 2017
    Keywords: Electronic structure and strongly correlated systems
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
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  • 3
    Publication Date: 2014-01-07
    Description: Author(s): H. Schaefer, V. V. Kabanov, and J. Demsar The interplay between the electronic and structural subsystems has strong implications on the character of collective excitations in cooperative systems. Their detailed understanding can provide important information on the coupling mechanisms and coupling strengths in such systems. With the recent ... [Phys. Rev. B 89, 045106] Published Mon Jan 06, 2014
    Keywords: Electronic structure and strongly correlated systems
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
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  • 4
    Publication Date: 2014-03-05
    Description: Author(s): V. V. Baranov and V. V. Kabanov The theory of the electron relaxation in simple metals excited by an ultrashort optical pump is developed on the basis of the solution of the linearized Boltzmann kinetic equation. The kinetic equation includes both the electron-electron and the electron-phonon collision integrals and assumes that F... [Phys. Rev. B 89, 125102] Published Tue Mar 04, 2014
    Keywords: Electronic structure and strongly correlated systems
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
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  • 5
    ISSN: 1573-904X
    Keywords: block copolymer ; intestinal delivery ; drug ; micelles
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Purpose. The present work characterizes the effects of Pluronic copolymers on the transport of a P-gp-dependent probe, rhodamine 123 (R123) in Caco-2 cell monolayers. Methods. The accumulation and efflux studies were performed on the confluent Caco-2 monolayers using fluorescent probes with and without Pluronic copolymers. Results. At concentrations below the critical micelle concentration single chains ("unimers”) of Pluronic P85 enhanced the accumulation and inhibited the efflux of R123 in Caco-2 monolayers. The transport of the P-gp-independent probe, rhodamine 110 was not altered under these conditions. In contrast the micelles increased R123 accumulation to a much lower extent when compared to the unimers and enhanced R123 efflux in Caco-2 monolayers. Conclusions. Pluronic P85 unimers increase accumulation of a P-gp-dependent drug in Caco-2 monolayers through inhibition of the P-gp efflux system. The mechanism of the micelle effect is not known, however, it is very similar to the micelle effects in BBMEC. This has been previously shown to involve vesicular transport of the micelle-incorporated drug. The study suggests that Pluronic copolymers can be useful in increasing oral absorption of select drugs.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1573-904X
    Keywords: pluronic block copolymer ; intestinal delivery ; drug ; micelles ; blood brain barrier
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Purpose. Using polarized bovine brain microvessel endothelial cells (BBMEC) monolayers as in vitro model of the blood brain barrier and Caco-2 monolayers as a model of the intestinal epithelium, the present work investigates the effects of Pluronic P85 block copolymer (P85) on the transport of the P-gycoprotein (P-gp)- dependent probe, rhodamine 123 (R123). Methods. The permeability and cell efflux studies are performed with the confluent cell monolayers using Side-Bi-Side diffusion cells. Results. At concentrations below the critical micelle concentration, P85 inhibits P-gp efflux systems of the BBMEC and Caco-2 cell monolayers resulting in an increase in the apical to basolateral permeability of R123. In contrast, at high concentrations of P85 the drug incorporates into the micelles, enters the cells and is then recycled back out to the apical side resulting in decrease in Rl 23 transport across the cell monolayers. Apical to basolateral permeability of micelle-incorporated R123 in BBMEC monolayers was increased by prior conjugation of P85 with insulin, suggesting that modified micelles undergo receptor-mediated transcytosis. Conclusions. Pluronic block copolymers can increase membrane transport and transcellular permeability in brain microvessel endothelial cells and intestinal epithelium cells. This suggests that these block copolymers may be useful in designing formulations to increase brain and oral absorption of select drugs.
    Type of Medium: Electronic Resource
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