ISSN:
1432-1041
Keywords:
Analgesic
;
antipyretic
;
antiphlogistic
;
intestinal absorption
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The excretion kinetics and blood levels of alclofenac (14C-carbonyl) have been investigated in 9 patients treated orally (400, 800 or 1200 mg single dose) or rectally (400 mg single dose). The results obtained have shown that: 1) the absorption and excretion of oral alclofenac are highly effective and rapid at the dose levels tested; 2) the blood levels are directly dose-related but cannot be correlated quantiatively with the urinary excretion; 3) binding of the drug to erythrocytes is only detectable at high blood levels; 4) rectal and oral administration are equally effective; 5) the analgesic activity of alclofenac is related to its blood concentrations.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00572460
Permalink