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Age differences in drug binding by plasma proteins: Studies on human foetuses, neonates and adults (1971)

Ehrnebo, M. ; Agurell, S. ; Jalling, B. ; [et al.]

Springer

European journal of clinical pharmacology 3 (1971), S. 189-193

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ISSN: 1432-1041

Keywords: Protein binding ; foetus ; infant ; newborn ; antibiotics ; anticonvulsants

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary The binding to human plasma proteins of ampicillin, α-azidobenzylpenicillin, benzylpenicillin, phenobarbital and diphenylhydantoin was studied by equilibrium dialysis of labelled compounds. Human foetal and neonatal plasma had very low binding capacities for all five drugs as compared with plasma from adults. Hyperbilirubinemia in the neonatal period further decreased the binding capacity. The age dependence of drug binding activity should be taken into account when analysing pharmacological effects in foetuses and newborn children.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00565004

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