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  • hypothyroidism  (2)
  • Benzophenone photosensitized cycloaddition  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Renal vascular reactivity to ATP in hyper- and hypothyroid rats (1996)
    Springer
    Cellular and molecular life sciences 52 (1996), S. 225-229 
    Details
    ISSN: 1420-9071
    Keywords: Hyperthyroidism ; hypothyroidism ; vasodilation ; vasoconstriction ; adenosine triphosphate (ATP) ; isolated kidney
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The effects of adenosine triphosphate (ATP) on the renal vasculature of isolated kidneys from control, hyper- and hypothyroid rats were characterized. ATP responsiveness was evaluated in basal tone and in raised tone (phenylephrine 10−6 M) preparations. These responses were compared with those obtained with barium chloride or sodium nitroprusside (SNP), used respectively as nonreceptor agonists for vasoconstriction or vasodilation. In preparations at basal tone, ATP produced dose-related vasoconstriction, which was increased in hyperthyroid kidneys, and was severely attenuated in kidneys from hypothyroid rats. In raised tone preparations from control rats ATP produced a dual response: vasoconstriction at low doses, which declined with increasing doses to give way to vasodilator responses; biphasic responses were found in some kidneys. Hyperthroid kidneys showed increased pressor responses and a vasodilator response similar to those seen in kidneys from control rats. However, in hypothyroid kidneys the vasodilator response was abolished. The responses to barium chloride and to SNP were significantly increased and decreased in hyper- and hypothyroid kidneys, respectively; vasoconstrictor responses to SNP were also found in hypothyroid kidneys. Hence the abnormal responses to ATP observed in both thyroid dysfunctions may be partially explained by unspecific alterations in the contractile machinery of the renal vasculature in these kidneys. However, ATP responsiveness (vasoconstriction at low tone and vasodilation at raised tone) was more severely affected in hypothyroid kidneys, suggesting that purinergic (P2X and P2Y) receptor activity may be decreased in these organs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01920711
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  • 2
    Electronic Resource
    Electronic Resource
    Photocycloaddition of 2,3-dimethylmaleimide to selenophene and 3,4-dimethylselenophene (1994)
    Springer
    Monatshefte für Chemie 125 (1994), S. 1153-1158 
    Details
    ISSN: 1434-4475
    Keywords: Photocycloaddition ; Selenophene ; Dimethylmaleimide ; Benzophenone photosensitized cycloaddition
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Die benzophenonsensitivierte Photocycloaddition von 2,3-Dimethylmaleimid an Selenophen und 3,4-Dimethylselenophen wurde durchgeführt, um erstens die Photoadditionsreaktionen von Methylmaleinsäureanhydridderivaten an Selenophen allgemein zu studieren und um zweitens die Zusammensetzung der bei der Reaktion gebildeten Produktgemische erneut zu untersuchen. Zusätzich zu dem bei früheren Arbeiten gefundenen 1:1-Addukt werden drei geometrische Isomere für das 2:1 — Addukt (2 Moleküle Maleimid und 1 Molekül Selenophen oder 3,4-Dimethylselenophen) vorgeschlagen.
    Notes: Summary The benzophenone sensitized photocycloaddition of 2,3-dimethylmaleimide to selenophene and 3,4-dimethylselenophene was carried out first to generalize the photoaddition reaction of methylmaleic anhydride derivatives to selenophene, using this time the nitrogen analogue, and second to reexamine the composition of the product mixture formed in the reaction. It was found that in adition to the 1:1 adduct isolated in previous investigations, three geometrical isomers may be proposed for the 2:1 adduct (two molecules of maleimide of one of selenophene or its methyl derivative).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00811523
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  • 3
    Electronic Resource
    Electronic Resource
    Methimazole treatment reduces cardiac hypertrophy and mortality without a concomitant reduction in blood pressure in established Goldblatt two-kidney one clip hypertension (1992)
    Springer
    Cellular and molecular life sciences 48 (1992), S. 755-758 
    Details
    ISSN: 1420-9071
    Keywords: Goldblatt two-kidney one clip hypertension ; methimazole ; hypothyroidism ; relative cardiac hypertrophy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The effects of methimazole, and antithyroid drug, on blood pressure and other parameters were evaluated in the established phase of Goldblatt two-kidney one clip (G2K-1C) hypertension. Methimazole was administered via drinking water for five weeks, starting five weeks after hypertension had been induced. After this period of treatment, similarly high blood pressures were observed in methimazole-treated and non-treated G2K-1C rats, despite the fact that a hypothyroid state had been achieved in methimazole-treated rats. Methimazole-treated G2K-1C rats showed reductions in heart rate, ventricular weight, ventricular/body weight ratio and mortality in comparison with rats not treated with methimazole. These results clearly demonstrate that hypothyroidism induced by methimazole: a) does not reverse G2K-1C hypertension, but b) improves the rate of survival and c) reduces relative cardiac hypertrophy, possibly by the reduction in cardiac work observed in Goldblatt hypothyroid rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02124296
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