ISSN:
1432-1041
Keywords:
Dilevalol
;
oxprenolol
;
hypertension
;
emotional stress
;
haemodynamic changes
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The effect of a single dose of 200 mg dilevalol, β-adrenoceptor blocker with additional vasodilating properties, and 200 mg oxprenolol on haemodynamic changes induced by emotional stress have been compared in 12 male young Caucasian patients with newly diagnosed labile hypertension. No difference was noted in the stress-induced increase of total peripheral resistance (TPR) following administration of the two substances (11% versus 6%). However, dilevalol revealed a vasodilating action by decreasing TPR at rest (from 1004 to 951 dyn·s·cm−5) and diastolic blood pressure (BP) (from 87 to 75 mm Hg) whereas TPR at rest remained unchanged after the intake of oxprenolol.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00315141
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