ISSN:
1617-4623
Keywords:
Mitomycin C
;
Transposable elements
;
Homologous recombination
;
gypsy (mdg4)
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Summary Mitomycin C was injected into the abdomen of male flies of the y 2 sc1 waG strain of Drosophila melanogaster. They were mated with females bearing attached-X chromosomes, and the male offspring (F1) were analysed for the appearance of mutations in the X chromosome. We observed y 1 and sc + reversions induced either by excision of mdg4 (gypsy) with retention of one long terminal repeat (LTR) or by insertion of a foreign sequence into mdg4, partial reversion of the w aG mutation, w aG→w aGd, and unstable f mutations. The overall mutation frequency was considerably higher than in control flies of the y 2 sc1 waG strain. Possible mechanisms of genomic rearrangements induced by Mitomycin C, in particular the role of homologous recombination, are discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00260486
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