ISSN:
1573-8221
Keywords:
glutathione peroxidase
;
glutathione reductase
;
tumor growth
;
sarcolysin
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract A decrease in glutathione peroxidase and glutathione reductase activity in sarcoma C-45 was discovered during the period of its most rapid growth. Repeated injections of sarcolysin (1.2 mg/kg, intraperitoneally) caused a sharp decrease in the activity of both enzymes and a simultaneous decrease in the ratio between glutathione reductase and glutathione peroxidase activities. It is suggested that the glutathione redox enzyme system plays an important role in the mechanisms of the antitumor action of chemotherapeutic agents.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00801698
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