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  • gastrointestinal transit  (5)
  • Springer  (5)
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  • Springer  (5)
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  • 1
    Electronic Resource
    Electronic Resource
    The Effect of Oleic Acid on the Human Ileal Brake and Its Implications for Small Intestinal Transit of Tablet Formulations (1999)
    Springer
    Pharmaceutical research 16 (1999), S. 92-96 
    Details
    ISSN: 1573-904X
    Keywords: ileal brake ; oleic acid ; tablets ; gastrointestinal transit ; scintigraphy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Purpose. A human volunteer study was carried out to investigate whether activation of the ileal brake mechanism affects the transit of tablets through the small intestine. Methods. Oleic acid, which has previously been shown to activate the brake, was delivered to the small intestine in a modified release capsule at doses of 300 mg, 600 mg and 1200 mg. The effect of the oleic acid was determined by measuring the transit of two sets of radiolabelled tablets by gamma scintigraphy. One set of tablets was dosed with the capsule and the other one hour later. Results. The results show that in the majority of the volunteers small intestinal residence time was greater with the oleic acid than control. The effect was most pronounced in the tablets given concomitantly with the capsule and with the higher doses of oleic acid. Conclusions. The ileal brake, activated by oleic acid, can slow the transit of tablets through the small intestine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018827030210
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  • 2
    Electronic Resource
    Electronic Resource
    Correlation of Phenylpropanolamine Bioavailability with Gastrointestinal Transit by Scintigraphic Monitoring of 111In-Labeled Hydroxypropylmethylcellulose Matrices (1989)
    Springer
    Pharmaceutical research 6 (1989), S. 274-278 
    Details
    ISSN: 1573-904X
    Keywords: bioavailability ; scintigraphy ; gastrointestinal transit ; controlled release ; phenylpropanolamine ; hydroxypropylmethylcellulose
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Two controlled-release hydroxypropylmethylcellulose (HPMC) matrix formulations, a single-unit and a multiple-unit system, have been evaluated in human volunteers. Both formulations contained the sympathomimetic drug phenylpropanolamine hydrochloride and each was radiolabeled with 111Inbound Amberlite IR 120 ion-exchange resin. The formulations were administered to each of six healthy male volunteers and gastrointestinal (GI) transit was monitored using a gamma camera. Serum samples were taken at set time intervals and assayed for phenylpropanolamine content, thus allowing blood drug levels to be correlated with the position of the dosage form in the GI tract. The multiple-unit system emptied from the stomach gradually over a period of about 180 min, when administered after a light breakfast, whereas the single-unit dosage forms had extremely variable gastric emptying times (range, 60 to 〉570 min). However, both formulations provided prolonged phenylpropanolamine blood levels. The differences in the blood profiles obtained with the two formulations were attributed to variations in their in vitro release rates and not to any differences in their GI transit times.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1015986121822
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  • 3
    Electronic Resource
    Electronic Resource
    Variation in Gastrointestinal Transit of Pharmaceutical Dosage Forms in Healthy Subjects (1991)
    Springer
    Pharmaceutical research 8 (1991), S. 360-364 
    Details
    ISSN: 1573-904X
    Keywords: gamma scintigraphy ; variability ; gastrointestinal transit ; pharmaceutical dosage forms
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The variability in the gastrointestinal transit of a multiple-unit and single-unit dosage form was investigated following a light breakfast in six, healthy, male volunteers after repeated weekly administration. The dosage forms were labeled with gamma-emitting radionuclides and the transit of the formulations was monitored on 4 separate study days using the technique of dual-isotope gamma scintigraphy. Gastric emptying times and small intestinal transit times were calculated and compared statistically within and between subjects using the standard deviation and coefficient of variance. The variability in gastric emptying of single- and multiple-unit systems was large; the intrasubject variation being less than the intersubject. There was less variation in small intestinal transit times for the single- and multiple-unit formulations than in gastric emptying, intrasubject variation again being less than intersubject variation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1015849700421
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  • 4
    Electronic Resource
    Electronic Resource
    In Vivo Evaluation of Enteric-Coated Naproxen Tablets Using Gamma Scintigraphy (1992)
    Springer
    Pharmaceutical research 9 (1992), S. 1436-1441 
    Details
    ISSN: 1573-904X
    Keywords: naproxen ; enteric-coated tablets ; samarium-153 ; neutron activation ; gastrointestinal transit
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Seven healthy, male volunteers were entered into a randomized, open crossover study of the gastrointestinal transit of two enteric-coated 500-mg naproxen tablets. Two radiolabeled tablets were given to each volunteer on two occasions separated by 7 days, once in the fasted state and once after breakfast. Radiolabeling of tablets was achieved by the incorporation of samarium-152 oxide during manufacture, followed by neutron activation of the tablet to produce the gamma-emitting isotope samarium-153. No loss of tablet integrity was seen in the stomach and all tablets disintegrated in the small intestine. Onset of tablet disintegration was controlled predominantly by gastric emptying. Time in the small intestine prior to tablet disintegration was independent of food intake. Naproxen blood levels with time were consistent with the delayed release of naproxen from the tablets. Overall, transit, disintegration, and absorption were as expected from an enteric-coated tablet.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1015858829187
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  • 5
    Electronic Resource
    Electronic Resource
    The effect of density on the gastric emptying of single- and multiple-unit dosage forms (1986)
    Springer
    Pharmaceutical research 3 (1986), S. 208-213 
    Details
    ISSN: 1573-904X
    Keywords: gastrointestinal transit ; pellet density ; floating formulations, gastric emptying
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The gastric emptying of pellets and single units of different densities has been followed in healthy subjects using the technique of gamma scintigraphy. The gastric emptying of the light pellets was affected by their buoyancy in the upper part of the stomach. However, the mean gastric emptying rates of pellets and single units were not significantly affected by density. Floating or buoyant delivery systems may have little advantage over conventional systems. The presence of food in the stomach was found to be the major factor in determining the gastric emptying of single units.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1016334629169
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