ISSN:
1573-9023
Keywords:
aliphatic hydrocarbon/water partitioning
;
calculation procedures
;
fragmental methods
;
lipophilicity
;
octanol/water partitioning
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Lipophilicity is a prime physicochemical parameter in describing both pharmacodynamic and pharmacokinetic aspects of drug action. Its quantitative descriptor (log P) is measured in or calculated for different model solvent systems depending on the respective scientific interest. The first part of this article focuses on the hydrophobic fragmental constant approach (Σf system) for octanol/water partitioning. The original approach and its revisions are presented, followed by recipes for the practical procedure ofΣf calculations and a detailed description of how to apply the correction factor CM.A Σf system for application in the study of aliphatic hydrocarbon/water (ahc/w) partitioning is described in the second part of the article. The current version is based on an optimized coupling of the ahc/w system with f constants for octanol/water partitioning. A total of 70 f ahc values are now available.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1008782809845
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