ISSN:
1420-9071
Keywords:
Phenylbutazone
;
stomach ulcers
;
food-deprivation
;
rats
;
food-deprived
;
stomach lesion scores
;
ulcer susceptibility
;
genetic differences in
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary Roman high-avoidance (RHA/Verh) rats, food-deprived (F-D) for 5 days, had higher stomach lesion scores than did F-D Roman low-avoidance (RLA/Verh) rats. F-D RLA/Verh rats which were injected i.p. with phenylbutazone (PBZ) 24 h before examination, however, had higher scores than did PBZ-treated, F-D RHA/-Verh rats. Histologically, extensive edema and cellular infiltration (including numerous erythrocytes) were seen below lesions, in the submucosa, denoting vascular damage. An attenuating influence of food on the ulcerogenic effects of PBZ, which were much more severe in F-D than in fed rats was also indicated.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01946462
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