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Eudismic analysis of a series of muscarinic ligands carrying a 1,3-oxathiolane nucleus (1990)

Gualtieri, F. ; Romanelli, M. N. ; Teodori, E.

New York, NY [u.a.] : Wiley-Blackwell

Chirality 2 (1990), S. 79-84

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ISSN: 0899-0042

Keywords: eudismic analysis ; muscarinic ligands ; muscarinic receptors sub-groups ; Chemistry ; Organic Chemistry

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: Eudismic analysis was performed on a set of 14 muscarinic ligands carrying a 1,3-oxathiolane nucleus, in order to obtain information about both the existence of receptor subgroups and of agonist and competitive antagonist interaction sites. The results obtained were compared with those from a study of the enantioselectivity of the pairs of enantiomers. The two approaches do not appear to be completely equivalent and would seem to complement each other usefully.

Additional Material: 4 Ill.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1002/chir.530020204

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