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  • 1
    Electronic Resource
    Electronic Resource
    Genetic analysis of tolerance to ethanol hypothermia in recombinant inbred mice: Effect of desglycinamide(9)-Arginine(8)-vasopressin (1980)
    Springer
    Behavior genetics 10 (1980), S. 139-152 
    Details
    ISSN: 1573-3297
    Keywords: recombinant inbred strains ; ethanol ; tolerance ; hypothermia ; mouse ; strain differences ; vasopressin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract The hypothermic effect of ethanol, tolerance to ethanol hypothermia, and the effect of desglycinamide(9)-Arginine(8)-vasopressin dicitrate (DGAVP) on ethanol hypothermic tolerance were investigated in Bailey's Recombinant Inbred strains of mice. Strains differed markedly in baseline temperatures and initial sensitivity to ethanol. There were no significant strain differences in tolerance. DGAVP attenuated the strain differences in initial sensitivity to ethanol and blocked tolerance development. These effects were accompanied by changes in the pattern of genetic control.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01066264
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  • 2
    Electronic Resource
    Electronic Resource
    Response to selection for sensitivity to ethanol hypothermia: Genetic analyses (1990)
    Springer
    Behavior genetics 20 (1990), S. 473-480 
    Details
    ISSN: 1573-3297
    Keywords: ethanol ; hypothermia ; selection ; HOT mice ; COLD mice ; heritability ; pharmacogenetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract Selective breeding has been used to produce lines of mice differing in sensitivity to the hypothermic effects of ethanol (EtOH). Two genetically independent HOT (insensitive) and two COLD (sensitive) lines are maintained along with two nonselected control (CON) lines. The breeding program is currently in selected generation 14, and HOT and COLD mice differ by about 4°C in selected hypothermic response. Estimates of heritability indicate that approximately 20% of the variance in EtOH-induced hypothermic response in mice is of additive genetic origin. Inbreeding has increased at a rate of about 1.7% per generation and no fertility problems have been detected as a result of selection. Projects designed to evaluate apparent correlated responses to selection are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01067713
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  • 3
    Electronic Resource
    Electronic Resource
    Selective breeding for alcohol withdrawal severity (1993)
    Springer
    Behavior genetics 23 (1993), S. 171-177 
    Details
    ISSN: 1573-3297
    Keywords: Withdrawal Seizure Prone (WSP)- and Resistant (WSR)- selected lines ; ethanol ; acute withdrawal ; seizure susceptibility ; tolerance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract Mouse lines have been genetically selected to be alcohol Withdrawal Seizure Prone (WSP) or Resistant (WSR). The selection index is the severity of withdrawal handling-induced convulsions seen after removal of mice from chronic exposure to ethanol vapor. Behavioral, pharmacological, and neurochemical results from a replicated bidirectional selection project are reviewed. In reciprocal F1 crosses of the WSP and WSR lines, substantial dominance for resistance to withdrawal was found in both replicated sets of lines. WSP and WSR mice differ principally, and markedly, in traits related to the severity of withdrawal from alcohols and other drugs with depressant properties. This suggests that genes influencing severity of withdrawal from chronic ethanol exposure also pleiotropically influence genetic susceptibility to dependence on other drugs of abuse. However, the results of WSP vs. WSR comparisons for traits related to ethanol sensitivity and tolerance development suggest control in large part by genes different from those influencing withdrawal severity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01067422
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