ISSN:
1573-904X
Keywords:
epithelial cell cultures
;
endothelial cell cultures
;
transport of drugs
;
cell culture
;
cell culture, intestinal, rectal, buccal, sublingual, nasal, ophthalmic
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract In an effort to develop novel strategies for delivery of drug candidates arising from rational drug design and recombinant DNA technology, pharmaceutical scientists have begun to employ the techniques of cell culture to study drug transport and metabolism at specific biological barriers. This review describes some of the general factors that should be considered in developing a cell culture model for transport studies and metabolism studies. In addition, we review in detail the recent progress that has been made in establishing, validating, and using cell cultures of epithelial barriers (e.g., cells that constitute the intestinal, rectal, buccal, sublingual, nasal, and ophthalmic mucosa as well as the epidermis of the skin) and the endothelial barriers (e.g., brain microvessel endothelial cells).
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1015800312910
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