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Digitale Medien

Protein kinase C activity following exposure to magnetic field and phorbol ester (1998)

Tuinstra, R. ; Goodman, E. ; Greenebaum, B.

New York, NY [u.a.] : Wiley-Blackwell

Bioelectromagnetics 19 (1998), S. 469-476

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ISSN: 0197-8462

Schlagwort(e): HL60 cells ; 60 Hz magnetic fields ; transduction mechanism(s) ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Biologie , Physik

Notizen: We examined the separate and combined effects of 60 Hz sinusoidal magnetic fields (MFs) and a phorbol ester on protein kinase C (PKC) activity in HL60 cells. No enhancement in PKC activity was observed when a cell culture was exposed to a 1.1 mT (rms) MF alone or to a combination of MF and 2 μM phorbol 12-myristate 13-acetate (PMA) for 1 h. In a second set of experiments, cells were preexposed to a less than optimal concentration of PMA (50 nM) for 45 min, followed by a 15 min exposure to both PMA and MF. The data showed a greater decrease in cytosolic PKC activity and a larger increase in membrane activity than was induced by either 1 h PMA treatment alone or PMA and sham MF exposure. One logical conclusion from these data is that MFs may be acting in a synergistic manner on a pathway that has already been activated. Therefore, we suggest that MFs, rather than producing biological effects by a new pathway or mechanism of interaction, exert their effect(s) by interacting with already functioning reactions or pathways. If correct, the question of an MF's mechanism of interaction refocuses on how weak fields might enhance or depress a molecular reaction in progress, rather than on finding a new transduction pathway. Bioelectromagnetics 19:469-476, 1998. © 1998 Wiley-Liss, Inc.

Zusätzliches Material: 2 Ill.

Materialart: Digitale Medien

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Digitale Medien

Effects of sinusoidal 60-Hz electric and magnetic fields on ATP and oxygen levels in the slime mold, Physarum polycephalum (1986)

Marron, M. T. ; Goodman, E. M. ; Greenebaum, B. ; [weitere]

New York, NY [u.a.] : Wiley-Blackwell

Bioelectromagnetics 7 (1986), S. 307-314

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ISSN: 0197-8462

Schlagwort(e): ATP ; respiration rate ; electromagnetic fields ; electric fields ; magnetic fields ; Physarum ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Biologie , Physik

Notizen: We have previously reported that exposing the vegetative plasmodia stage of Physarum polycephalum to either individual or simultaneously applied electric and magnetic fields (45-75 Hz, 0.14-2.0 G, and 0.035-0.7 V/m) lengthens their mitotic cycle, depresses their rate of reversible shuttle streaming, and lowers their respiration rate. In this article we report the effects of simultaneously applied electromagnetic fields (60 Hz, 1.0 G, 1.0 V/m), electric fields only (60 Hz, 1.0 V/m), magnetic fields only (60 Hz, 1.0 G) on the haploid amoeba of Physarum exposed for 120-180 days. Statistically significant depressions (about 8-11%) in ATP levels were observed with all field conditions; however, respiration was significantly decreased only when amoebae were subjected to either combined fields or electric fields alone. Magnetic fields alone failed to induce a significant decrease in respiration.

Zusätzliches Material: 2 Tab.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bem.2250070307

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