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  • Tyrosinase  (1)
  • elastic property  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Tyrosinase epitope recognized by an HLA-DR-restricted T-cell line from a Vogt-Koyanagi-Harada disease patient (1998)
    Springer
    Immunogenetics 47 (1998), S. 398-403 
    Details
    ISSN: 1432-1211
    Keywords: Key words HLA ; Peptide ; VKH disease ; Tyrosinase ; T-cell response
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  Human T-cell-mediated autoimmune diseases are often genetically linked to particular alleles of HLA class II genes. Vogt-Koyanagi-Harada’s (VKH) disease, which is regarded as an autoimmune disorder in multiple organs containing melanocytes, has been found to be associated with HLA-DR4 (DRB1*0405) and HLA-DR53 (DRB4*0101). Tyrosinase is a melanoma antigen (Ag) expressed by normal melanocytes as well as melanoma cells against which responses by autologous T cells have been detected. We established a T-cell line from the peripheral blood of a patient with VKH disease which responded to synthetic peptides corresponding to tyrosinase. The T-cell line was generated which recognized the tyrosinase p188 – 208 peptide when presented by the HLA-DR4 (DRB1*0405) molecule on the surface of HLA class II-expressing L-cell transfectants. The minimal antigenic peptide which induced T-cell responses was an 11-amino-acid sequence and located at tyrosinase p193 – 203 (E-I-W-R-D-I-D-F-A-H-E). This peptide contained the DRB1*0405-binding peptide motif (hydrophobic residues (Y, F, W) at position 1 as an anchor residue, and negatively charged residues (D, E) at position 9), which corresponded to the W at p195 and the D at p203. These observations demonstrate that tyrosinase peptides are immunogenic, and may be a candidate for an autoantigen in VKH disease, suggesting that probing the T-cell responses against synthetic peptides is a productive approach for identifying the autoantigenic peptides associated with autoimmune diseases including VKH disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002510050375
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  • 2
    Electronic Resource
    Electronic Resource
    Swelling behavior of the filling-type membrane (1997)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part B: Polymer Physics 35 (1997), S. 469-477 
    Details
    ISSN: 0887-6266
    Keywords: polymer solution ; elastic property ; polyethylene ; polymer swelling ; membrane ; Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: A model that can express the swelling of the filling-type membrane was developed by modifying a model that was developed for a crystalline polymer. The filling-type membrane is composed of two different polymers. One is porous substrate and another is a polymer that filled pores of the substrate. The filling technique can effectively suppress polymer swelling due to the substrate matrix. The model needs two parameters: one is a unit ratio of tie segments in the substrate to the filling polymer, f, which can express a mechanical strength of the substrate, and another is the Flory interaction parameter, χ, between the filling polymer and a solvent that expresses a mixing energy. A porous high-density polyethylene film was used as a porous substrate, and plasma-graft filling polymerization technique could make the filling-type membrane. Methylacrylate was used as a grafting monomer that filled the pores of substrate. A swelling behavior of the filling-type membrane and pure poly(methylacrylate) were measured by the vapor sorption method at different solvent activities. The model was in good agreement with experimental results for the filling-type membrane. Using the model, swelling of the filling-type polymer was compared with a crosslinked polymer, which can be expressed by Flory and Rehner model. The comparison showed that the filling technique is a good way to suppress polymer swelling, and a high crosslinking density is needed to obtain the same level of swelling suppression effect the filling type membrane showed. © 1997 John Wiley & Sons, Inc.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
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