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  • Articles  (2)
  • differential scanning calorimetry  (2)
  • Springer  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Interaction of furosemide with lipid membranes (1988)
    Springer
    The journal of membrane biology 101 (1988), S. 103-111 
    Details
    ISSN: 1432-1424
    Keywords: Furosemide ; partition into lipids ; differential scanning calorimetry ; PLM ; conductance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary The interaction of furosemide with different phospholipids was investigated. Its influence on the lipid structure was inferred from its effect on the phase transition properties of lipids and on the conductance of planar bilayer membranes. The thermotropic properties of dipalmitoyl phosphatidylcholine, phosphatidylethanolamine (natural), dipalmitoyl phosphatidylethanolamine, brain sphingomyelin, brain cerebrosides and phosphatidylserine in the presence and absence of furosemide were investigated by differential scanning calorimetry,. The modifying effect of furosemide seems to be strongest on phosphatidylethanolamine (natural) and sphingomyelin bilayers. The propensity of furosemide to decrease the electrical resistance of planar lipid membranes was also studied and it is shown that the drug facilitates the transport of ions. Partition coefficients of furosemide between lipid bilayers and water were measured.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01872825
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  • 2
    Electronic Resource
    Electronic Resource
    Perturbations of membrane structure by optical probes: II. Differential scanning calorimetry of dipalmitoyllecithin and its analogs interacting with merocyanine 540 (1980)
    Springer
    The journal of membrane biology 54 (1980), S. 141-148 
    Details
    ISSN: 1432-1424
    Keywords: Optical probes ; lipid bilayer ; differential scanning calorimetry ; structural perturbance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary Differential scanning calorimetry of multilamellar liposomes, interacting with the optical probe Merocyanine 540, yields quantitative information about perturbances of the bilayer structure induced by this dye. At low dye: lipid ratios, the dye perturbs primarily its own microenvironment, which is laterally separated from the unmodified lipid domain and exhibits modified thermotropic properties. A further increase in the dye concentration results in a perturbance of the whole lipid bilayer. The degree of perturbance is sensitive to structural modifications in the head-group region of the lipids. It is concluded that Merocyanine 540 reports in every case, even at infinite dilution, on localized events originating from a perturbed microenvironment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01940567
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    Paper (German National Licenses)
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