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  • 1
    Electronic Resource
    Electronic Resource
    Decreased plasma membrane fluidity of peripheral blood lymphocytes after diethyldithiocarbamate (DTC) therapy in HIV-infected patients (1989)
    Springer
    European journal of clinical pharmacology 37 (1989), S. 521-523 
    Details
    ISSN: 1432-1041
    Keywords: diethyldithiocarbamate (DTC) ; human immunodeficiency virus (HIV) ; plasma membrane fluidity ; fluorescence anisotropy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In seeking the putative mechanism of action of diethyldithiocarbamate (DTC) on the immune status of HIV infected patients, the plasma membrane fluidity of peripheral blood lymphocytes (PBL) from DTC-treated and untreated patients (CDC III-IVc1) was determined. Anisotropy values of the fluorescent probe 6-(9-anthroyloxy) stearic acid were increased in DTC-treated patients (0.175 vs 0.161), indicating decreased PBL plasma membrane fluidity. The membrane rigidifying effect was significantly greater 4 h after i.v. drug administration (0.185 in treated patients). As the membrane fluidity and the function of membrane embedded antigen are interdependent, it is possible that alterations in biophysical and/or biochemical properties of membranes may account for the beneficial effect of DTC on the immune function and clinical status of HIV infected patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558135
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  • 2
    Electronic Resource
    Electronic Resource
    New prototype NIRS to investigate multi-regional cerebral blood and tissue oxygenation and haemodynamics (2000)
    Springer
    Medical & biological engineering & computing 38 (2000), S. 281-286 
    Details
    ISSN: 1741-0444
    Keywords: Near intra-red spectroscopy ; Optical multiplexing ; Multi-regional ; Cerebral ; PVL
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Near infra-red spectroscopy (NIRS) is a non-invasive optical technique used to assess blood and tissue oxygenation and haemodynamics in living tissue. It is presently used as a semi-continuous monitoring technique on a research basis. Multi-regional NIRS information could be beneficial for a better understanding of the development of cerebral injuries and the reduction of neurodevelopmental abnormalities in the human newborn. The paper presents the conversion of the continuous wave NIRS single-channel instrument (NIRDCU) into a prototype four-channel instrument which can be used to provide continuous multi-regional information regarding the cerebral blood oxygenation and haemodynamics in the frontal, left parietal, right parietal and occipital region of the neonatal brain. This has been achieved by attaching an optical multiplexing system to the NIRDCU to select different transmitting and receiving fibres, thus addressing different regions in the brain. Preliminary laboratory tests on a phantom and on the adult forearm are presented, illustrating the practicality of regional monitoring.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02347048
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