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  • 1
    Electronic Resource
    Electronic Resource
    A comparison of the psychotropic profiles of tofisopam and diazepam (1982)
    Springer
    European journal of clinical pharmacology 22 (1982), S. 137-142 
    Details
    ISSN: 1432-1041
    Keywords: tofisopam ; diazepam ; electroencephalogram ; sedation ; pro-drug
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Twelve normal subjects were tested on a number of measures both before and 1,3 and 5 h after 10 mg diazepam, 100 and 200 mg tofisopam and a placebo. The measures included self-ratings of mood, bodily symptoms, hostility and sleep, the electroencephalogram (EEG), reaction time, tapping, digit symbol substitution, the symbol copying test, and plasma levels. Diazepam showed a clear profile of action, producing EEG changes, pronounced sedation and psychological impairment. The last two effects were maximal at 1 h and had worn off by 5 h. The EEG was recorded at 3 h only. Tofisopam in no way resembled diazepam. It produced no changes on the EEG or psychological tests and a very mild stimulant effect was apparent on the ratings. While diazepam was easily detectable in the blood, tofisopam did not bind to benzodiazepine receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542458
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  • 2
    Electronic Resource
    Electronic Resource
    Comparative effects of a repeated dose regime of diazepam and buspirone on subjective ratings, psychological tests and the EEG (1983)
    Springer
    European journal of clinical pharmacology 24 (1983), S. 463-467 
    Details
    ISSN: 1432-1041
    Keywords: buspirone ; diazepam ; electroencephalogram ; psychological impairment ; sedation ; side-effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Two doses of buspirone (5 and 10 mg tds), 1 dose of diazepam (5 mg tds) and placebo were administered to 8 normal subjects for a period of 8 days. Each subject received each drug in a balanced order with a minimum interval of 1 week between courses. Psychotropic effects were assessed with a battery of physiological, psychomotor and subjective tests on the first, third and last days of treatment both before the first daily dose and at 1 h and 3 h after it. Diazepam showed a characteristic profile of action producing EEG changes and psychological impairment after a single dose which were still present after a week's treatment. Such effects were minimal after buspirone. Both drugs increased subjective ratings of drowsiness but these feelings tended to decrease after a week's treatment on the clinical doses. Buspirone (10 mg tds) produced some unpleasant side-effects initially but tolerance to these invariably developed after 3 days treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00609887
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    Paper (German National Licenses)
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