ISSN:
1824-310X
Schlagwort(e):
long term memory
;
spike trains
;
dendritic spines
;
kinase II
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Biologie
Notizen:
Abstract Memory is the repetition of an even and this requires re-firing a sufficient number of neurons that did participate to the event. We assume that an event is identified by a digital code sealed into a molecular counter, kinase II, capable of taking billions of configurations. We also assume that spike trains represent numbers in binary notation that are able to code and decode kinase II. Coding means that a number is imprinted by setting kinase II in a certain configuration, decoding means activating kinase II carrying that number in order to liberate Ca2+ via Calmodulin and open the various segments of circuit where it is located. We assume that coded kinase II is stored in dendritic spines, adjacent to synapses, that protect in from metabolic destruction of the coding. The model easily interprets the fact that the same optical or olfactory stimuli will induce identical spike trains. Because identification requires the re-opening of a specific memory. So the smell of a rose must open the circuit of the rosesmell via the appropriate spike train.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF02437446
Permalink
