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  • 1
    Electronic Resource
    Electronic Resource
    Dehydroepiandrosterone and melatonin prevent Bacillus anthracis lethal toxin-induced TNF production in macrophages (2000)
    Springer
    Cell biology and toxicology 16 (2000), S. 165-174 
    Details
    ISSN: 1573-6822
    Keywords: anthrax lethal toxin ; cytokine ; dehydroepiandrosterone ; melatonin ; tumor necrosis factor α
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The lethal toxin of Bacillus anthracis, which is composed of two separate proteinaceous exotoxins, namely protective antigen and lethal factor, is central to the pathogenesis of anthrax. Low levels of this toxin are known to induce release of cytokines such as tumor necrosis factor α (TNF-α). In the present study we investigated the effect of dehydroepiandrosterone (DHEA), melatonin (MLT), or DHEA + MLT on production of lethal toxin-induced TNF-α in mouse peritoneal macrophages. We found that treatment with DHEA significantly inhibited the TNF-α production caused by anthrax lethal toxin. Exposure of MLT to anthrax lethal toxin-treated macrophages also decreased the release of TNF-α to the extracellular medium as compared to the control. However, combined use of DHEA and MLT also inhibited TNF-α release, but not more than single therapies. These results suggest that DHEA and MLT may have a therapeutic role in reducing the increased cytokine production induced by anthrax lethal toxin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007606921569
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  • 2
    Electronic Resource
    Electronic Resource
    Bifurcation analysis for a modified Jeffcott rotor with bearing clearances (1990)
    Springer
    Nonlinear dynamics 1 (1990), S. 221-241 
    Details
    ISSN: 1573-269X
    Keywords: Nonlinear ; rotor ; clearance ; chaos
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract A HB (Harmonic Balance)/AFT (Alternating Frequency/Time) technique is developed to obtain synchronous and subsynchronous whirling motions of a horizontal Jeffcott rotor with bearing clearances. The method utilizes an explicit Jacobian form for the iterative process which guarantees convergence at all parameter values. The method is shown to constitute a robust and accurate numerical scheme for the analysis of two dimensional nonlinear rotor problems. The stability analysis of the steady-state motions is obtained using perturbed equations about the periodic motions. The Floquet multipliers of the associated Monodromy matrix are determined using a new discrete HB/AFT method. Flip bifurcation boundaries were obtained which facilitated detection of possible rotor chaotic (irregular) motion as parameters of the system are changed. Quasi-periodic motion is also shown to occur as a result of a secondary Hopf bifurcation due to increase of the destabilizing cross-coupling stiffness coefficients in the rotor model.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01858295
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