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Action of KCN on intact and refractory platelets (1976)

Lisovskaya, I. L. ; Volkova, R. I. ; Pozin, E. Ya. ; [et al.]

Springer

Bulletin of experimental biology and medicine 82 (1976), S. 1170-1174

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ISSN: 1573-8221

Keywords: Platelets ; aggregation ; refractoriness ; ADP ; cyanide

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Abstract The action of potassium cyanide on ADP-induced aggregation of intact and refractory platelets was investigated. Cyanide (5·10−4 M) had virtually no effect on the aggregation of intact cells but stimulated aggregation of refractory platelets. The stimulating effect of the inhibitor on aggregation was not connected with liberation of further quantities of ADP from the cells. Differences in the sensitivity of the aggregating power of intact and refractory cells to partial depression of metabolism is discussed in terms of the “calcium” model of autoregulation of platelet aggregation suggested previously.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00785546

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