ISSN:
1573-1111
Keywords:
Crystallization
;
nucleation
;
crystal growth
;
polymorph
;
molecular complex
;
transformation
;
solvent effect
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The effect of the solvents acetone (AT), dimethylsulfoxide (DMSO) and methylcellosolve (MCS) on the inclusion of 2-acetylnaphthalene (2-AN) in the host, 1,1-di(p-hydroxyphenyl)cyclohexane (DHC) has been investigated. Each solvent molecule is included in DHC in a molar ratio of 1.0, when DHC is crystallized from the solvents. The evaporation rate of these solvents from the host lattice decreases in the order AT, MCS and DMSO. The order agrees well with the interaction strength between the host and solvent molecule, which was measured by DSC and IR. 2-AN cannot be included in the crystals by crystallization from MCS and DMSO solutions. However, in AT solution both AT and 2-AN are included competitively and the morphology of the crystals is different from that obtained in pure solution. The amount of 2-AN in the crystals increases continuously with its concentration in solution. This behavior indicates that AT is replaced by 2-AN and the solid solution of the molecular complex is formed. The solid solution is a metastable form and the solution-mediated tranformation to the stable form (which includes only AT) was observed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00706471
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