ISSN:
0947-6539
Keywords:
computer simulations
;
conformations
;
Lewis glycolipids
;
molecular dynamics
;
thioglycosides
;
Chemistry
;
General Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Several monomeric and dimeric Lewis glycolipids have been investigated by NMR spectroscopy, and structural aspects were modelled by computer. From the pseudo-C2-symmetric tetrasaccharide unit that forms the recognition domain of the Lewis Y and Lewis b antigens, a totally C2-symmetric tetrasaccharide was designed that contains the structural element common to all Lewis antigens. Finally, a model for the presentation of dimeric Lewis antigens at membrane surfaces was derived. The overall shapes of the dimeric Lewis oligosaccharides are defined by the connectivity of the sugar residues within rigid tri- and tetrasaccharide building blocks.
Additional Material:
9 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/chem.1460020811
Permalink
