ISSN:
1573-8221
Keywords:
hepatocyte
;
CCl 4
;
collagen degradation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Partial hepatectomy of mouse cirrhotic liver leads to rapid degeneration of hypertrophied connective tissue. Enlarged cisterns of the smooth endoplasmic reticulum lie close to the plasma membrane on the sinusoidal surface of hepatocyte. Golgi apparatus of Kupffer cells is hypertrophied, swollen collagen fibrils lose their specific striation. Microvilli of hepatocyte plasmalemma separate swollen collagen fibrils and draw them into the cytoplasm. Lysosomes, peroxisomes, and hypertrophied Golgi apparatus are spread from the sinusoidal surface to bile capillaries, which indicates that these structures are involved in collagen lysis and release of metabolites into the bile capillary. After partial hepatectomy of cirrhotic liver, hepatocytes, Kupffer cells, and neutrophils play the major role in collagen lysis. Kupffer cells and neutrophils are involved in the lysis of collagen fibrils during CCl4-induced liver cirrhosis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02433852
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