ISSN:
1573-3904
Keywords:
circular dichroism
;
electrospray ionization massspectrometry
;
noncovalent interactions
;
pairing of amino acids
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract During our work on the periodicity of the genetic code we proposed a new scheme of amino acid pairing [Siemion, I.Z. and Stefanowicz, P., Biosystems, 27 (1992) 77; Bull. Pol. Acad. Sci., 40 (1992) 11]. Based on this scheme, we designed and synthesized the sequences IIYTLC(Acm)GLYL (II), IIYPLC(Acm)GLYL (V), and IYPLC(Acm)GLY (VI), which are ‘antipeptides’ with respect to immunoactive fragments of TGFβ2: YIGKTPKI (III) and YYIGKTPKIE (IV). The peptide–antipeptide interaction was investigated by electrospray ionization mass spectrometry and circular dichroism methods. The results obtained indicate that peptides interact selectively with ‘antipeptides’.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1008882410436
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