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  • 1
    Electronic Resource
    Electronic Resource
    Esterase-30 (ES-30) of the house mouse: Biochemical characterization and genetics of a new carboxylesterase isozyme linked to cluster-2 loci on chromosome 8 (1993)
    Springer
    Biochemical genetics 31 (1993), S. 279-294 
    Details
    ISSN: 1573-4927
    Keywords: house mouse ; esterase-30 ; chromosome 8 ; gene order
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract A new carboxylesterase isozyme (EC 3.1.1.1), designated ES-30, is described in mouse liver. Two phenotypes were distinguished, ES-30A, a possible null type, was found in SPE/Pas and in other lines derived fromMus spretus, and ES-30B was found in BALB/cJ and other laboratory inbred strains. ES-30B is characterized by a distinct electrophoretic band when stained using 5-bromoindoxyl acetate as the substrate. After isolation and purification from other esterases by ion-exchange chromatography and molecular sieving, the molecular mass was estimated by two independent methods to be 62 and 64 kDa, respectively. The activity of ES-30B is higher in adult males than in females and can be stimulatedin vivo by testosterone. The distribution of phenotypes on the progeny of a backcross series suggests a separate locus,Es-30, with the allele a for absence andb for presence of the isozyme. LocusEs-30 is shown to be closely linked toEs-2 and toEs-7 of cluster-2 on chromosome 8. The gene orderEs-9—Got-2—(Es-2, Es-7, Es-30) is suggested.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00553171
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  • 2
    Electronic Resource
    Electronic Resource
    Esterase-30 (ES-30) of the house mouse: Biochemical characterization and genetics of a new carboxylesterase isozyme linked to cluster-2 loci on chromosome 8 (1993)
    Springer
    Biochemical genetics 31 (1993), S. 279-294 
    Details
    ISSN: 1573-4927
    Keywords: house mouse ; esterase-30 ; chromosome 8 ; gene order
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract A new carboxylesterase isozyme (EC 3.1.1.1), designated ES-30, is described in mouse liver. Two phenotypes were distinguished, ES-30A, a possible null type, was found in SPE/Pas and in other lines derived fromMus spretus, and ES-30B was found in BALB/cJ and other laboratory inbred strains. ES-30B is characterized by a distinct electrophoretic band when stained using 5-bromoindoxyl acetate as the substrate. After isolation and purification from other esterases by ion-exchange chromatography and molecular sieving, the molecular mass was estimated by two independent methods to be 62 and 64 kDa, respectively. The activity of ES-30B is higher in adult males than in females and can be stimulatedin vivo by testosterone. The distribution of phenotypes on the progeny of a backcross series suggests a separate locus,Es-30, with the allele a for absence andb for presence of the isozyme. LocusEs-30 is shown to be closely linked toEs-2 and toEs-7 of cluster-2 on chromosome 8. The gene orderEs-9—Got-2—(Es-2, Es-7, Es-30) is suggested.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02401823
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  • 3
    Electronic Resource
    Electronic Resource
    Genetic characterization of esterase 28 (ES-28) of the house mouse (1991)
    Springer
    Biochemical genetics 29 (1991), S. 55-63 
    Details
    ISSN: 1573-4927
    Keywords: Mus ; esterase-28 ; epididymis ; chromosome 8
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The genetics of esterase-28, the major esterase of cauda epididymidis of the house mouse, has been studied after separation by polyacrylamide gel electrophoresis and isoelectric focusing. Four phenotypes are distinguished. Segregation ofEs-28 in two backcross series indicated linkage to Es-1, Es-9, and Es-22. The Es-28 locus was placed into esterase cluster 1 on chromosome 8.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00578240
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  • 4
    Electronic Resource
    Electronic Resource
    Genetic and biochemical characterization of a new chymotrypsin isozyme of the house mouse, CTRA-1 (1991)
    Springer
    Biochemical genetics 29 (1991), S. 545-557 
    Details
    ISSN: 1573-4927
    Keywords: pancreas protease ; chymotrypsin A ; CTRA-1 ; mouse genetics ; chromosome 8
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Genetic variation of a codominantly inherited pancreas protease, designated CTRA-1, was discovered in the house mouse by isoelectric focusing in polyacrylamide gels. Phenotype CTRA-1A was found in MOLH/Fre and in the majority of common laboratory mouse strains. Phenotype CTRA-1B was found in PWD/Ph. It was characterized by the absence of a corresponding protease band. A third phenotype, CTRA-1C, was observed in IS/Cam and a fourth phenotype, CTRA-1D, was detected in SEG/1. CTRA-1 was found only in the pancreas and may represent the A form of chymotrypsin. The enzyme was shown to be controlled by the presumed structural locusCtra-1 located on chromosome 8. From two backcross series, including a total of 274 animals, the gene order(Es-1, Es-9)—3.9±1.7%—Got-2—3.9±1.7%—(Es-2, Es-7, Es-23)—0.7±0.5%—Ctra-1—6.3±2.2%—Prt-2 was established.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00554129
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  • 5
    Electronic Resource
    Electronic Resource
    Biochemistry and genetics of esterase-20 (ES-20), a second trimeric carboxylesterase of the house mouse (mus musculus). II. A unique recombination reveals ES-20 as a hybrid enzyme (1985)
    Springer
    Biochemical genetics 23 (1985), S. 759-770 
    Details
    ISSN: 1573-4927
    Keywords: Mus musculus ; chromosome 8 ; gene order ; hybrid enzyme
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract A unique recombination is described between (Es-1, Es-6) and (Es-9, Es-22) within gene cluster 1 of the esterase gene region on chromosome 8 of the house mouse. This recombination established the gene orderEs-1—Es-6—(Es-9, Es-22)—Got-2. A further 73 recombinations, from a total of 911 backcrosses, had taken place between cluster 1 and cluster 2. A distance between the clusters of 8.01±0.90% was calculated; the genes within the clusters appeared more tightly linked than previously assumed. ES-20 behaved anomalously following the recombination within cluster 1: homozygous descendants of the recombinant expressed a new form of ES-20.In vitro incubation of purified ES-6A3 and ES-9A generated ES-20A, revealing this esterase to be a hybrid of different cluster 1 gene products,Es-9 and possiblyEs-6. This result satisfactorily accounted for the genetic finding, as well as a range of biochemical properties of ES-20.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00554086
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  • 6
    Electronic Resource
    Electronic Resource
    Kidney esterases of Mus musculus: Further polymorphism of esterase-6, esterase-9, and a new esterase, esterase-20 (1982)
    Springer
    Biochemical genetics 20 (1982), S. 537-554 
    Details
    ISSN: 1573-4927
    Keywords: esterase ; chromosome 8 ; Mus musculus ; aggregation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The comparison of results obtained by different separation and staining techniques permits the definition of esterase-6 in comparison with esterase-9 and a new esterase, esterase-20. Alleles of Es-6 affect the product's ability to aggregate. Esterase-20 may be an aggregated product of Es-9. The close linkage of Es-6 and Es-9 is confirmed. Homology of esterase-6 with esterases from other mammalian species is also suggested.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00484703
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  • 7
    Electronic Resource
    Electronic Resource
    Esterase-23 (ES-23): Characterization of a new carboxylesterase isozyme (EC 3.1.1.1) of the house mouse, genetically linked to ES-2 on chromosome 8 (1984)
    Springer
    Biochemical genetics 22 (1984), S. 769-782 
    Details
    ISSN: 1573-4927
    Keywords: Mus musculus ; esterase ; temporal locus ; chromosome 8
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Genetic variation of a carboxylesterase isozyme (EC 3.1.1.1) of the house mouse, designated ES-23, is described. ES-23 was found in kidney, liver, and intestine. The isozyme was resistant to inhibition by 10−3 mol/liter eserine and was stained using α-naphthyl butyrate or 5-bromoindoxyl acetate as substrate. Five different phenotypes, ES-23A to ES-23E, could be distinguished by disc electrophoresis and by isoelectric focusing. ES-23 is controlled by a structural locus situated within the esterase gene cluster 2 on chromosome 8. An analysis of allele distribution among different strains suggested a separate structural locus for the isozyme, ES-23e, which is closely linked to the loci Es-2, Es-5, Es-7, and Es-11. Of the five phenotypes, only ES-23B was expressed in lung. This variation is apparently controlled by a cis-acting regulatory element, presumably a temporal locus, Es-23t, closely linked to the presumed structural locus Es-23e.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00499472
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  • 8
    Electronic Resource
    Electronic Resource
    Genetic and biochemical characterization of a new chymotrypsin isozyme of the house mouse, CTRA-1 (1991)
    Springer
    Biochemical genetics 29 (1991), S. 545-557 
    Details
    ISSN: 1573-4927
    Keywords: pancreas protease ; chymotrypsin A ; CTRA-1 ; mouse genetics ; chromosome 8
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Genetic variation of a codominantly inherited pancreas protease, designated CTRA-1, was discovered in the house mouse by isoelectric focusing in polyacrylamide gels. Phenotype CTRA-1A was found in MOLH/Fre and in the majority of common laboratory mouse strains. Phenotype CTRA-1B was found in PWD/Ph. It was characterized by the absence of a corresponding protease band. A third phenotype, CTRA-1C, was observed in IS/Cam and a fourth phenotype, CTRA-1D, was detected in SEG/1. CTRA-1 was found only in the pancreas and may represent the A form of chymotrypsin. The enzyme was shown to be controlled by the presumed structural locusCtra-1 located on chromosome 8. From two backcross series, including a total of 274 animals, the gene order(Es-1, Es-9)—3.9±1.7%—Got-2—3.9±1.7%—(Es-2, Es-7, Es-23)—0.7±0.5%—Ctra-1—6.3±2.2%—Prt-2 was established.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02426870
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  • 9
    Electronic Resource
    Electronic Resource
    Biochemistry and genetics of esterase-20 (ES-20), a second trimeric carboxylesterase of the house mouse (mus musculus). II. A unique recombination reveals ES-20 as a hybrid enzyme (1985)
    Springer
    Biochemical genetics 23 (1985), S. 759-770 
    Details
    ISSN: 1573-4927
    Keywords: Mus musculus ; chromosome 8 ; gene order ; hybrid enzyme
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract A unique recombination is described between (Es-1, Es-6) and (Es-9, Es-22) within gene cluster 1 of the esterase gene region on chromosome 8 of the house mouse. This recombination established the gene orderEs-1—Es-6—(Es-9, Es-22)—Got-2. A further 73 recombinations, from a total of 911 backcrosses, had taken place between cluster 1 and cluster 2. A distance between the clusters of 8.01±0.90% was calculated; the genes within the clusters appeared more tightly linked than previously assumed. ES-20 behaved anomalously following the recombination within cluster 1: homozygous descendants of the recombinant expressed a new form of ES-20.In vitro incubation of purified ES-6A3 and ES-9A generated ES-20A, revealing this esterase to be a hybrid of different cluster 1 gene products,Es-9 and possiblyEs-6. This result satisfactorily accounted for the genetic finding, as well as a range of biochemical properties of ES-20.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02399407
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