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Effects of chlorpromazine and other drugs acting on the central nervous system on human sperm motility (1982)

Hong, C. Y. ; Chaput de Saintonge, D. M. ; Turner, P.

Springer

European journal of clinical pharmacology 22 (1982), S. 413-416

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ISSN: 1432-1041

Keywords: chlorpromazine ; sperm motility ; central nervous system depressant ; caffeine ; membrane stabilizing effect ; fertility

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary The in vitro effects of chlorpromazine, diazepam, phenytoin and phenobarbitone on human sperm motility were investigated. Only chlorpromazine inhibits human sperm motility and the concentration which decreases sperm motility to 50% of control is 0.22 mM. Caffeine can shift the dose-response curve of chlorpromazine-inhibited sperm motility to right. We support the hypothesis that chlorpromazine acts on the cellular membrane but consider the inhibition of sperm motility an unlikely cause of decreased fertility in chlorpromazine treated patients.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00542545

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