ISSN:
1573-8221
Keywords:
Tuberculin
;
cellular immunity
;
macrophagal migration inhibiting factor
;
genetic control
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Inbred CBA and C57BL mice and (CBA×C57BL)F1 hybrids were immunized intraperitoneally with Freund's complete adjuvant and the production of macrophagal migration inhibiting factor (MIF) by lymphocytes in different situations was investigated. Lymphocytes were activated to produce MIF in a certain order: cells of the peritoneal exudate first, then lymph node cells and, finally, spleen cells. Maximal MIF production by lymphocytes of the peritoneal exudate was obtained in C57BL mice, and it occurred earlier (on the 3rd day after immunization). Increased spontaneous migration of macrophages also was observed after immunization and it was more marked in the CBA mice.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00785561
Permalink
