ISSN:
0006-3525
Keywords:
conformations of oligoprolines
;
cation-peptide complexes
;
x-ray structure
;
ion transport across membranes
;
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
To clarify the possible molecular mechanism of cation unit conductance of poly(D,L-proline) across lipidic membranes, the structure and conformation of tetraproline derivatives with different configurational sequences in solid state, as well as in solution and in the presence of alkali and alkali-earth ions, were investigated using x-ray analysis, CD, and nmr spectroscopy. The tetraproline derivatives Boc(D-Pro-L-Pro-L-Pro-D-Pro)OBg and Boc(L-Pro)4OBg show very different conformational versatilities in solutions as well as different propensities to form complexes with Ca2+ ion. This is interpreted, based on previous evidence, as due to different abilities to form ion complexing cavities. © 1998 John Wiley & Sons, Inc. Biopoly 45: 257-267, 1998
Additional Material:
15 Ill.
Type of Medium:
Electronic Resource
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