ISSN:
1352-8661
Keywords:
cerebral perfusion
;
dementia
;
Down's syndrome
;
CSF
;
MRI
;
brain aging
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
,
Physics
Notes:
Abstract The time evolution of the histogram (number of pixels versus signal intensity) is used to calculate ΔR 2 parameters from dynamic contrast-enhanced magnetic resonance (MR) imaging of the brain. This method partially corrects for partial volume effects and is an improvement over the approach using the signal intensity as a function of time when confounding factors such as changing cortical cerebrospinal fluid volumes are involved. The maximum value for ΔR 2 is found to correlate with relative cerebral blood flow as assessed by xenon inhalation and can be used to discriminate between vascular dementia and healthy volunteers. With this method, the normal range for ΔR 2 values is found to be the same for both young (19–40 years old) and elderly (65–85 years old) healthy volunteers.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02426399
Permalink
