ISSN:
1432-1041
Keywords:
prenalterol
;
chronic renal failure
;
metoprolol
;
blood pressure
;
cardiac index
;
stroke volume index
;
transmural myocardial perfusion
;
left ventricular ejection fraction
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The acute haemodynamic effects of the beta-adrenoreceptor agonist, prenalterol, were studied in six patients with chronic end-stage renal failure. Prenalterol 0.8 mg, 1.6 mg, and 3.2 mg was administered i.v. as a bolus, and after the last dose the selective adrenergic beta-1-receptor antagonist metoprolol was administered i.v. in doses of 5 and 10 mg. The haemodynamic effects of the drugs were investigated using impedance cardiography and radionuclide angiocardiography. The main haemodynamic effects were a dose-related chronotropic effect, demonstrated by an increase in heart rate (26%; 〈0.05), and an inotropic effect, shown by an increase in stroke volume index (20%;p〈0.05) and left ventricular ejection time (12%;p〈0.05); the cardiac index was increased by 47% (p〈0.05). Transmural myocardial perfusion (DPTI/SPTI ratio) was decreased by 22% (p〈0.05) after prenalterol. It is concluded that prenalterol has positive inotropic and chronotropic effects in patients with chronic renal failure, that the improvement in left ventricular performance is at the expense of a decreased transmural myocardial perfusion, and that metoprolol is a specific antidote.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01037935
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