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  • Picloram  (2)
  • bisantrene  (2)
  • Springer  (4)
  • 1
    Electronic Resource
    Electronic Resource
    Continuous callus production and regeneration of garlic (Allium sativum L.) using root segments from shoot tip-derived plantlets (1998)
    Springer
    Plant cell reports 17 (1998), S. 726-730 
    Details
    ISSN: 1432-203X
    Keywords: Key words Garlic ; Allium sativum L. ; Root segments ; Regeneration ; Picloram
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Root segments from shoot tip-derived plantlets of the garlic (Allium sativum L.) clones `DDR7099', `PI383819', and `Piacenza' were utilized as an explant source for continuous, friable callus production. The best callus production occurred on root segments initially cultured on medium with 4,5 μm 2,4-dichlorophenoxyacetic acid (2,4-D) for 8 weeks, then subcultured to medium with 4.7 μm 4-amino-3,5,6-trichloropicolinic acid (picloram) +0.49 μm 6-(γ-γ-dimethylallylamino)purine (2iP) for 8 weeks. Embryogenic, friable callus was transferred to liquid medium for 1 month and then transferred to solid regeneration medium for 14 weeks. The best shoot and root regeneration (85.3% and 35.8%, respectively) occurred on 4-month-old calli from the clone `DDR7099'. In all clones, regeneration rate decreased as callus age increased.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002990050473
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  • 2
    Electronic Resource
    Electronic Resource
    Regeneration of garlic callus as affected by clonal variation, plant growth regulators and culture conditions over time (1999)
    Springer
    Plant cell reports 19 (1999), S. 32-36 
    Details
    ISSN: 1432-203X
    Keywords: Key words Allium sativum ; Benzyladenine ; Picloram ; Thidiazuron ; 2 ; 4-D ; 2iP
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  A long-term regeneration system for garlic (Allium sativum L.) clones of diverse origin was developed. Callus was initiated on a modified Gamborg's B-5 medium supplemented with 4.5 μM 2,4-D and maintained on the same basal medium with 4.7 μM picloram+0.49 μM 2iP. Regeneration potential of callus after 5, 12 and 16 months on maintenance medium was measured using several plant growth regulator treatments. The 1.4 μM picloram+13.3 μM BA treatment stimulated the highest rate of shoot production. Regeneration rate decreased as callus age increased, but healthy plantlets from callus cultures up to 16-months-old were produced for all clones. Regeneration of long-term garlic callus cultures could be useful for clonal propagation and transformation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002990050706
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  • 3
    Electronic Resource
    Electronic Resource
    Anaphylactoid reactions associated with bisantrene infusions (1983)
    Springer
    Investigational new drugs 1 (1983), S. 85-88 
    Details
    ISSN: 1573-0646
    Keywords: bisantrene ; hypersensitivity ; histamine release
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Nine of ninety-three patients receiving Bisantrene on an every three week schedule developed an anaphylactoid reaction with a variety of symptoms. Most reactions occurred in patients who had multiple exposures to Bisantrene. Investigatiors utilizing Bisantrene in ongoing clinical trials should be aware of this life threatening toxicity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00180195
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  • 4
    Electronic Resource
    Electronic Resource
    Characterization of the pharmacokinetics of bisantrene (NSC-337766) (1983)
    Springer
    Investigational new drugs 1 (1983), S. 253-258 
    Details
    ISSN: 1573-0646
    Keywords: bisantrene ; CL216,942 ; pharmacokinetics in humans
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of bisantrene, 9,10-anthracenedicarboxaldehyde bis ((4,5-dihydro-1 H-imidazol-2-yl) hydrazone) dihydrochloride were evaluated during a Phase I clinical investigation. Bisantrene at doses of 20 to 280 mg/m2 was administered by variable infusion rates to nine patients with advanced metastatic cancer. Bisantrene's plasma clearance followed a triexponential pattern with a harmonic mean terminal half-life (t1/2 γ) of 26 h. The steady state volume of distribution (Vd ss ) was large, averaging 627 l/m2. Plasma clearance averaged 42.6±6.7 l/h/m2. The cumulative urinary excretion of bisantrene was 3.6±1.6% at 48 h.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00208899
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