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Relative bioavailability of a paracetamol suppository (1980)

Seideman, P. ; Alván, G. ; Andrews, R. S. ; [et al.]

Springer

European journal of clinical pharmacology 17 (1980), S. 465-468

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ISSN: 1432-1041

Keywords: paracetamol ; suppository ; tablets ; bioavailability

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary The relative bioavailability of a new paracetamol suppository (Panodil) and tablets in doses of 0.5 and 1 g was investigated in eight healthy subjects. The tablets were absorbed faster and higher peak plasma concentrations were obtained than after the suppositories. The bioavailability of the suppositories was approximately 80% of that of the tablets at both dose levels. There was no indication of capacity-limited elimination at either the two doses investigated.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00570165

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