ISSN:
1432-1041
Keywords:
Key words Serotonin
;
Zacopride; ACTH secretion
;
cortisol secretion
;
benzamide derivatives
;
5-HT4 receptor
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Abstract Objective: In the present study, we investigated the effect of zacopride on corticotropin (ACTH) and cortisol secretion in healthy volunteers. Male subjects received a single oral dose of placebo, 10 μg zacopride or 400 μg zacopride. Plasma ACTH, cortisol and aldosterone concentrations were measured before and during the 3 h following the administration of the drug. Results: For none of the doses did zacopride cause any modification of plasma ACTH or cortisol levels. In contrast, administration of 400 μg zacopride induced a significant increase in plasma aldosterone levels. Conclusion: Our results indicate that in humans serotonin-evoked stimulation of ACTH secretion is not mediated through serotonin4 (5-HT4) receptors. Together with previous findings, these data indicate that the stimulatory effect of 5-HT4 receptor agonists on aldosterone secretion in man can be ascribed solely to a direct action on glomerulosa cells.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002280050159
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