ISSN:
1432-1041
Schlagwort(e):
theophylline
;
asthma
;
slow release theophylline
;
reversible obstructive airways disease
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Chemie und Pharmazie
,
Medizin
Notizen:
Summary Theophylline concentrations were measured in a clinical setting in 15 patients given a slow release theophylline preparation (Theo-Dur) every 12 h for reversible obstructive airways disease. Doses of 300–600 mg (464±134), 12 hourly, resulted in mean serum concentrations which increased from 11.2±2.9 µg/ml at 0 h to a peak of 15.5±4.6 µg/ml at 6 h and decreased again to 10.4±2.9 µg/ml at 12 h. The mean percentage fluctuation of serum concentrations (maximum minus minimum expressed as a % of the maximum) was 38.6±10.1%, range 20.3% to 54.9%. There was a significant positive correlation between % fluctuation and theophylline steady-state clearance determinations. Excluding a single heavy smoker, theophylline clearance also showed a significant inverse relationship with age. These data suggest that when this slow release preparation is given 12 hourly, satisfactorily sustained serum theophylline concentrations will be achieved in most adults.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00613818
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