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  • antihypertensive therapy  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    Pafenolol, a new β1-selective blocking agent, in mild hypertension. Result of an inpatient study and a subsequent outpatient follow-up (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 549-553 
    Details
    ISSN: 1432-1041
    Keywords: pafenolol ; hypertension ; antihypertensive therapy ; beta1-blocking agent ; exercise tests ; plasma levels
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Pafenolol, a new selective adrenergic beta1-blocking agent, has been tested for the first time in 6 hypertensive patients. After single oral doses of pafenolol 25 to 100 mg, there was a marked reduction in heart rate and systolic blood pressure during exercise tests. These effects were dose dependent. A significant positive correlation was found between the reduction in heart rate during exercise and the plasma level of pafenolol 5 hours after drug intake (correlation coefficient r=0.94). Side effects were mild and seemed to be dose dependent. It is concluded that this new beta1-blocking agent was effective in reducing blood pressure and was well tolerated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00543483
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Sleep disturbances, nightmares and other possible central nervous disturbances in a population sample of women, with special reference to those on antihypertensive drugs (1980)
    Springer
    European journal of clinical pharmacology 17 (1980), S. 173-177 
    Details
    ISSN: 1432-1041
    Keywords: antihypertensive therapy ; sleep disturbances ; depression ; nightmares ; population study ; women
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Of 1302 women aged 44–66 years in a population study in Göteborg, Sweden, in 1974–75, who were representative of women of all the ages studied in the area, 165 were taking antihypertensive drugs, mostly β-blockers and diuretics. The prevalence of sleep disturbances, nightmares, tiredness and melancholia or depression was studied in the total population sample, and a comparison was made between women who were or were not taking antihypertensive drugs. In the entire population sample no significant difference was found between the various age strata studied, although with increasing age there was a trend towards fewer complaints of nightmares, but a larger number of sleep disturbances as a whole. No difference was found between women taking or not taking various types of single-drug therapy or combinations of antihypertensive drugs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00561896
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    Paper (German National Licenses)
    Fulltext
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