ISSN:
0899-0042
Keywords:
chiral HPLC
;
amylose tris(3,5-dimethylphenylcarbamate)
;
cellulose tris(3,5-dimethylphenylcarbamate)
;
cellulose tris(4-methylbenzoate)
;
imine enantiomers
;
e.e. determination
;
imine isomerization reaction
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
A high-performance liquid chromatographic method has been developed for the analysis of the intermediate imines and end products in an asymmetric isomerization route toward optically active amines. Separation of the imine enantiomers was performed on commercially available Chiralcel OD-H, Chiralcel OJ, and Chiralpak AD chiral stationary phases. All substituted imine enantiomers could be readily resolved with selectivities (α) higher than 1.10 using the Chiralpak AD column. By derivatization with ring-substituted benzaldehydes, aromatic amines were converted into Schiff base derivatives and the enantiopurity of these amines was determined. Chirality 9:727-731, 1997. © 1997 Wiley-Liss, Inc.
Additional Material:
3 Ill.
Type of Medium:
Electronic Resource
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