ISSN:
1420-9071
Keywords:
Zona pellucida glycoproteins
;
adjuvant
;
immunoblotting
;
enzyme-linked immunosorbent assay
;
autoantibodies
;
infertility
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary Rhesus monkeys evoked a vigorous antibody response to a single heteroimmunization dose of zona pellucida antigens, when these were administered along with complete Freud's adjuvant. The antisera recognized all the three major porcine zona glycoprotein families and the animals were rendered amenorrheic after such immunization. Monkeys immunized with zona without adjuvant, however, failed to show any anti-zona antibody response and had normal menstrual cycles. Zona pellucida glycoproteins are thus not effective immunogens unless administered along with a powerful adjuvant.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01974580
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