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  • acridine organge  (1)
  • aggregating power  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Evaluation of the ability of intact platelets to accumulate acridine organge (1988)
    Springer
    Cellular and molecular life sciences 44 (1988), S. 616-618 
    Details
    ISSN: 1420-9071
    Keywords: Platelets ; acridine organge ; storage granules ; fluorescence quenching ; accumulation ability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A new approach to the evaluation of the uptake of fluorescent, probes by intact, cells is described. Acridine organe (AO) was used because it can be selectively accumulated by serotonin-containing granules of platelets. Analysis of the fluorescence signal allows the estimation of the relative volume of the granules and the equilibrium coefficients for AO transport across the cytoplasm and granule membranes. The following results were obtained for human and rabbit platelets: the relative volumes of the granules were 14±1% and 29±2%, the ratios of intragranular-extracellular probe concentration were 2260±382 and 30,000±5500, and the cytoplasm-extracellular medium concentration ratios were 375±60 and 225±60, respectively.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01953316
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of liposomes on platelet function (1979)
    Springer
    Bulletin of experimental biology and medicine 88 (1979), S. 828-831 
    Details
    ISSN: 1573-8221
    Keywords: liposomes ; platelets ; aggregating power ; spherulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The effect of different types of liposomes on the dynamic functions of platelets was studied. Liposomes of different composition (containing cholesterol and phosphatidylcholinethanolamine or not) and charge (containing negatively charged dicetyl phosphate or not) were shown to cause qualitatively similar but quantitatively slightly different effects and to modify the properties of the platelets: to reduce their powers of aggregation and their spherulation. The tendency for the platelets to aggregate was reduced by an increase in the concentration of liposomes, by an increase in the duration of incubation of the platelets with liposomes, and by the change from ordinary lecithin liposomes to liposomes containing phosphatidylcholinethanolamine. Suggestions are put forward regarding the mechanism of the observed phenomena and the absence of an unfavorable effect of various liposomes on platelet function is noted.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00869205
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    Paper (German National Licenses)
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